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コテラ ヨシヒト
KOTERA Yoshihito
小寺 由人 所属 医学部 医学科（東京女子医科大学病院） 職種 非常勤講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Long-term outcome of liver resection for colorectal metastases in the presence of extrahepatic disease: A multi-institutional Japanese study. |
| 掲載誌名 | 正式名：Journal of hepato-biliary-pancreatic sciences 略 称：J Hepatobiliary Pancreat Sci ISSNコード：18686982/18686974 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 27(11),pp.810-818 |
| 著者・共著者 | Sawada Yu, Sahara Kota, Endo Itaru, Sakamoto Katsunori, Honda Goro, Beppu Toru, Kotake Kenjiro, Yamamoto Masakazu, Takahashi Keiichi, Hasegawa Kiyoshi, Itabashi Michio, Hashiguchi Yojiro, Kotera Yoshihito, Kobayashi Shin, Yamaguchi Tatsuro, Tabuchi Ken, Kobayashi Hirotoshi, Yamaguchi Kensei, Morita Satoshi, Natsume Soichiro, Miyazaki Masaru, Sugihara Kenichi |
| 発行年月 | 2020/11 |
| 概要 | BACKGROUND/PURPOSE:The purpose of the present study was to assess long-term outcomes following liver resection for colorectal liver metastases (CRLM) with concurrent extrahepatic disease and to identify the preoperative prognostic factors for selection of operative candidates.METHODS:In this retrospective, multi-institutional study, 3820 patients diagnosed with CRLM during 2005-2007 were identified using nationwide survey data. Data of identified patients with concurrent extrahepatic lesions were analyzed to estimate the impact of liver resection on overall survival (OS) and to identify preoperative, prognostic indicators.RESULTS:Three- and 5-year OS rates after liver resection in 251 CRLM patients with extrahepatic disease (lung, n = 116; lymph node, n = 51; peritoneal, n = 37; multiple sites, n = 23) were 50.2% and 32.0%, respectively. Multivariate analysis revealed that a primary tumor in the right colon, lymph node metastasis from the primary tumor, serum carbohydrate antigen (CA) 19-9 level >37 UI/mL, the site of extrahepatic disease, and residual liver tumor after hepatectomy were associated with higher mortality. We proposed a preoperative risk scoring system based on these factors that adequately discriminated 5-year OS after liver resection in training and validation datasets.CONCLUSIONS:Performing R0 liver resection for colorectal liver metastases with treatable extrahepatic disease may prolong survival. Our proposed scoring system may help select appropriate candidates for liver resection. |
| DOI | 10.1002/jhbp.810 |
| PMID | 32713080 |