MORIMOTO Satoshi
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Characteristics of neutralizing antibody titers of the SARS-CoV-2 vaccine in maintenance hemodialysis patients.
Journal Formal name：Clinical nephrology
Abbreviation：Clin Nephrol
ISSN code：03010430/03010430
Domestic / ForeginForegin
Volume, Issue, Page 101(6),pp.271-276
Author and coauthor Amari Yoshifum†, Morimoto Satoshi*, Teranishi Takashi, Motoike Yu, Yurugi Takatomi, Oyama Yasuo, Nakajima Fumitaka, Kobayashi Hitoshi
Authorship 2nd author,Corresponding author
Publication date 2024/06
Summary AIMS:Hemodialysis patients have high COVID-19 severity and mortality rates. For this high-risk group of hemodialysis patients with SARS-CoV-2 infection, early SARS-CoV-2 vaccination is recommended to prevent infection and severe disease. Thus far, few reports have evaluated COVID-19 antibody titers in hemodialysis patients. In this study, we investigated the time course of antibody titers acquired by vaccination in patients on dialysis.MATERIALS AND METHODS:The anti-SARS-CoV-2 spike protein S1 IgG (anti-SP-IgG) antibody titers were compared between 33 outpatient maintenance hemodialysis patients and 32 age- and sex-matched healthy subjects. Antibody tests were performed at five time points: 6 months after the 2nd vaccination, immediately before the 3rd vaccination (8 months after the 2nd vaccination), and 2 weeks, 1 month, and 3 months after the 3rd vaccination.RESULTS:The dialysis patient group had significantly lower values of anti-SP-IgG antibody titers than the control group 6 months after the 2nd vaccination (433.7 ± 36.24 vs. 650.2 (427.2 - 759.4) (AU/mL), p = 0.006) and immediately before the 3rd vaccination (219.3 (129.4 - 423.4) vs. 443.3 (267.1 - 600.4) (AU/mL), p = 0.034), but no significant differences were observed after the 3rd vaccination (19,000.0 (11,000.0 - 3,6000.0) vs. 23,500.0 (20,250.0 - 29,000.0) (AU/mL), p = 0.538).CONCLUSION:This study confirmed that patients undergoing hemodialysis were proven to have acquired sufficient antibody titers after the vaccination.
DOI 10.5414/CN111179
PMID 38497683