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MORIMOTO Satoshi
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
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| Article types | Case report |
| Language | English |
| Peer review | Peer reviewed |
| Title | A case report of interferon beta monotherapy for high hepatitis C viral load in dialysis patients. |
| Journal | Formal name：Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Abbreviation：Ther Apher Dial ISSN code：17449979/17449979 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 11(4),pp.306-8 |
| Author and coauthor | Nakajima Fumitaka, Fukii Masayoshi, Kitamura Testuya, Sakaida Aya, Sakaguchi Masahiro, Oka Hiroshi, Morimoto Satoshi, Masaki Hiroya, Yamahara Hideki, Shibahara Nobuhisa, Inoue Toru |
| Publication date | 2007/08 |
| Summary | A 42-year-old male dialysis patient was infected with hepatitis C virus (HCV), and treated with interferon beta (IFN-beta) for a rapid increase in viral load. After dialysis three times a week, 3 million units of IFN-beta were intravenously infused for 1 h. The treatment was markedly effective, and the virus was eliminated in the sixth week. Therapy was continued for 24 weeks, and HCV negativity has been maintained for more than 6 months after the completion of administration. The blood IFN level slowly decreased immediately after administration. The mean trough level was 37 U/mL, and the half-life was 65 min. No adverse event requiring discontinuation of the treatment occurred, showing that IFN alone may safely eliminate the virus in dialysis patients with high hepatitis C viral load. Many dialysis patients are latently infected with HCV, and the infection affects the prognosis. Therefore, establishment of a therapeutic method is urgently needed. |
| DOI | 10.1111/j.1744-9987.2007.00488.x |
| PMID | 17661838 |