MORIMOTO Satoshi
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Case report
Language English
Peer review Peer reviewed
Title A case report of interferon beta monotherapy for high hepatitis C viral load in dialysis patients.
Journal Formal name:Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Abbreviation:Ther Apher Dial
ISSN code:17449979/17449979
Domestic / ForeginForegin
Volume, Issue, Page 11(4),pp.306-8
Author and coauthor Nakajima Fumitaka, Fukii Masayoshi, Kitamura Testuya, Sakaida Aya, Sakaguchi Masahiro, Oka Hiroshi, Morimoto Satoshi, Masaki Hiroya, Yamahara Hideki, Shibahara Nobuhisa, Inoue Toru
Publication date 2007/08
Summary A 42-year-old male dialysis patient was infected with hepatitis C virus (HCV), and treated with interferon beta (IFN-beta) for a rapid increase in viral load. After dialysis three times a week, 3 million units of IFN-beta were intravenously infused for 1 h. The treatment was markedly effective, and the virus was eliminated in the sixth week. Therapy was continued for 24 weeks, and HCV negativity has been maintained for more than 6 months after the completion of administration. The blood IFN level slowly decreased immediately after administration. The mean trough level was 37 U/mL, and the half-life was 65 min. No adverse event requiring discontinuation of the treatment occurred, showing that IFN alone may safely eliminate the virus in dialysis patients with high hepatitis C viral load. Many dialysis patients are latently infected with HCV, and the infection affects the prognosis. Therefore, establishment of a therapeutic method is urgently needed.
DOI 10.1111/j.1744-9987.2007.00488.x
PMID 17661838