モリモト　サトシ   MORIMOTO Satoshi   森本　聡    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	A case report of interferon beta monotherapy for high hepatitis C viral load in dialysis patients.
掲載誌名	正式名：Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 略　 称：Ther Apher Dial ISSNコード：17449979/17449979
掲載区分	国外
巻・号・頁	11(4),pp.306-8
著者・共著者	Nakajima Fumitaka, Fukii Masayoshi, Kitamura Testuya, Sakaida Aya, Sakaguchi Masahiro, Oka Hiroshi, Morimoto Satoshi, Masaki Hiroya, Yamahara Hideki, Shibahara Nobuhisa, Inoue Toru
発行年月	2007/08
概要	A 42-year-old male dialysis patient was infected with hepatitis C virus (HCV), and treated with interferon beta (IFN-beta) for a rapid increase in viral load. After dialysis three times a week, 3 million units of IFN-beta were intravenously infused for 1 h. The treatment was markedly effective, and the virus was eliminated in the sixth week. Therapy was continued for 24 weeks, and HCV negativity has been maintained for more than 6 months after the completion of administration. The blood IFN level slowly decreased immediately after administration. The mean trough level was 37 U/mL, and the half-life was 65 min. No adverse event requiring discontinuation of the treatment occurred, showing that IFN alone may safely eliminate the virus in dialysis patients with high hepatitis C viral load. Many dialysis patients are latently infected with HCV, and the infection affects the prognosis. Therefore, establishment of a therapeutic method is urgently needed.
DOI	10.1111/j.1744-9987.2007.00488.x
PMID	17661838