MORIMOTO Satoshi    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Associate Professor
Article types	Case report
Language	English
Peer review	Peer reviewed
Title	The efficacy of indomethacin in the treatment of uremic pericarditis.
Journal	Formal name：Nihon Jinzo Gakkai shi Abbreviation：Nihon Jinzo Gakkai Shi ISSN code：03852385/03852385
Domestic / Foregin	Foregin
Volume, Issue, Page	37(2),pp.140-4
Author and coauthor	Morimoto S†*, Katoh S, Inoue K, Terashima S, Tatsukawa H, Ida K
Authorship	Lead author,Corresponding author
Publication date	1995/02
Summary	Uremic pericarditis is common in patients undergoing chronic hemodialysis and has been difficult to cure using conservative medical and surgical methods of treatment. Indomethacin therapy for uremic pericarditis has been reported infrequently. We present a case of uremic pericarditis in which indomethacin was particularly effective. The patient was a 45-year-old woman with thrombocytopenia due to Banti's syndrome and congestive heart failure with pericardial effusion. She had been undergoing hemodialysis for 3 years for chronic renal failure due to chronic glomerulonephritis. Uremic pericarditis was diagnosed based on serological laboratory results, aspirated pericardial fluid, and an echocardiogram. She was treated with oral doses of 25 mg t.i.d. indomethacin in addition to hemodialysis and extracorporeal ultrafiltration method. Pericardial effusion and left ventricular dysfunction disappeared after indomethacin therapy for 38 days. There are conflicting reports on the efficacy of indomethacin therapy in patients with uremic pericarditis. While indomethacin therapy was very effective in our case, there may be many causes of uremic pericarditis for which indomethacin may not be efficacious. Further investigations of indomethacin therapy for patients with uremic pericarditis are necessary to elucidate the therapeutic mechanism by which indomethacin acts.
PMID	7752506