MORIMOTO Satoshi
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
|
Article types | Review article |
Language | English |
Peer review | Peer reviewed |
Presence of invitation | Invited paper |
Title | Critical appraisal and pooled analysis of telmisartan alone or in combination with hydrochlorothiazide for achieving blood pressure goals. |
Journal | Formal name:Integrated blood pressure control Abbreviation:Integr Blood Press Control ISSN code:11787104/11787104 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 3,pp.73-9 |
Author and coauthor | Morimoto Satoshi†*, Takahashi Nobuyuki, Morita Tatsuyori, Someya Kazunori, Toyoda Nagaoki, Iwasaka Toshiji |
Authorship | Lead author,Corresponding author |
Publication date | 2010 |
Summary | Rigid control of blood pressure (BP) is essential to prevent cardiovascular disease. However, only about 40% of hypertensive patients undergoing pharmacological intervention with a single agent achieve their BP goals in contemporary clinical practice. Combined therapy using currently available agents is effective in maximizing treatment outcome, although it raises medical costs and decreases the drug compliance rate. To overcome such negative consequences, a combination tablet containing an angiotensin II receptor blocker (ARB) with a small dose of hydrochlorothiazide (HCTZ) is now available on the international market, including Japan. This article briefly describes the unique properties of telmisartan, a highly selective ARB for the angiotensin II type 1 receptor, including its long-acting characteristics and recent prospective multicenter randomized clinical trials, followed by a description of a newly-introduced combination tablet in Japan, which contains telmisartan and HCTZ. This article also reviews its safety and efficacy based on currently available evidence. Finally, evidence comparing telmisartan/HCTZ with other combination therapies is presented. |
DOI | 10.2147/ibpc.s9325 |
PMID | 21949623 |