モリモト　サトシ   MORIMOTO Satoshi   森本　聡    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prognostic significance of ankle-brachial index, brachial-ankle pulse wave velocity, flow-mediated dilation, and nitroglycerin-mediated dilation in end-stage renal disease.
掲載誌名	正式名：American journal of nephrology 略　 称：Am J Nephrol ISSNコード：14219670/02508095
掲載区分	国外
巻・号・頁	30(1),pp.55-63
著者・共著者	Morimoto Satoshi†*, Yurugi Takatomi, Aota Yasuko, Sakuma Takao, Jo Fusakazu, Nishikawa Mitsushige, Iwasaka Toshiji, Maki Kei
担当区分	筆頭著者,責任著者
発行年月	2009
概要	BACKGROUND:Identifying patients at high risk of cardiovascular disease is important in managing patients undergoing hemodialysis.METHODS:We evaluated a series of prognostic values: flow-mediated dilation (FMD) and nitrogen-mediated dilation (NMD), an index of endothelium-dependent and endothelium-independent function, respectively, ankle-brachial index (ABI), and brachial-ankle pulse wave velocity (baPWV) in patients undergoing chronic hemodialysis.RESULTS:A cohort of 199 patients was studied. At entry, these values were examined and the prognostic significances were investigated. In estimating the significance of baPWV, patients with ABI <0.9 were excluded. During the follow-up period, 24 deaths occurred including 14 cardiovascular and 10 noncardiovascular fatal events. Overall, the survival rates were significantly lower in the low ABI than in the high ABI group, but the survival rates were not significantly different between the high and low FMD, NMD, or baPWV groups. Cardiovascular survival rates were significantly lower in the low ABI than in the high ABI group, and in the high baPWV than in the low baPWV group. The survival rates were not significantly different between the high and low FMD or NMD groups.CONCLUSIONS:Screening hemodialysis patients by means of ABI and baPWV but not FMD or NMD provides complementary information in identifying a high-risk population in these patients.
DOI	10.1159/000201416
PMID	19204388