MORIMOTO Satoshi    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Associate Professor
Article types	Review article
Language	English
Peer review	Peer reviewed
Title	Angiotensin mutant mice: a focus on the brain renin-angiotensin system.
Journal	Formal name：Neuropeptides Abbreviation：Neuropeptides ISSN code：01434179/01434179
Domestic / Foregin	Foregin
Volume, Issue, Page	36(2-3),pp.194-200
Author and coauthor	Morimoto Satoshi†, Sigmund Curt D
Authorship	Lead author
Publication date	2002
Summary	With advances in genetic manipulation and molecular biological and physiological techniques, the mouse has become the animal model of choice for studying the genetic basis of human diseases. The two most commonly used methods for analyzing the function of a gene in vivo, overexpression (transgenic mouse) and deletion (knockout mouse), have been extremely useful in establishing the importance of genes in genetic disorders. The renin-angiotensin system (RAS) is one of the most widely studied systems controlling blood pressure. Although the primary site of Ang-II production is the plasma, all the components of the RAS cascade are expressed in many tissues, including the brain. This review briefly summarizes systemic and tissue-specific transgenic and knockout mouse models of the RAS for determining the role of this system in the regulation of blood pressure and in the pathogenesis of hypertension, with a focus on the RAS in the brain.
DOI	10.1054/npep.2002.0894
PMID	12359509