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MORIMOTO Satoshi
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
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| Article types | Case report |
| Language | English |
| Peer review | Peer reviewed |
| Title | Loperamide therapy in a patient with diarrhea and resistant hypertension. |
| Journal | Formal name：American journal of hypertension Abbreviation：Am J Hypertens ISSN code：08957061/08957061 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 13(4 Pt 1),pp.431-2 |
| Author and coauthor | Morimoto S†*, Sasaki S, Itoh H, Nakata T, Takeda K, Nakagawa M |
| Authorship | 2nd author |
| Publication date | 2000/04 |
| Summary | A 65-year-old man was admitted to our hospital for resistant essential hypertension. He had a past history of bowel resections due to Crohn's disease. We assumed that in this patient insufficient drug absorption might be a cause of resistant hypertension and that even increased antihypertensive regimens would fail to decrease blood pressure. We administered loperamide, which may increase drug absorption from the residual intestine. Blood pressure was successfully decreased, with a concomitant increase in blood concentration of antihypertensive drugs. In patients with impaired drug absorption, we should make an effort to restore drug obstruction before considering increased drug regimens. |
| DOI | 10.1016/s0895-7061(99)00231-9 |
| PMID | 10821347 |