モリモト　サトシ   MORIMOTO Satoshi   森本　聡    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Blockade of angiotensin II receptors inhibits the increase in blood pressure induced by insulin.
掲載誌名	正式名：Journal of cardiovascular pharmacology 略　 称：J Cardiovasc Pharmacol ISSNコード：01602446/01602446
掲載区分	国外
巻・号・頁	31(2),pp.248-52
著者・共著者	Nakata T, Takeda K, Hatta T, Kiyama M, Moriguchi J, Miki S, Kawa T, Morimoto S, Nakamura K, Uchida A, Itoh H, Sasaki S, Nakagawa M
発行年月	1998/02
概要	To elucidate whether hyperinsulinemia increases blood pressure by increasing sympathetic outflow via the activation of the central angiotensin system, insulin was infused into urethane-anesthetized rats intravenously (i.v.) or intracerebroventricularly (i.c.v.) under euglycemic conditions. Infusion (i.v.) of insulin elicited pressor effects in a dose-dependent manner (13, 20, and 40 mU/min). Although depressor responses to i.v. injections of hexamethonium were significantly greater in insulin-infused than in saline-infused rats, i.v. captopril and d(CH2)5Tyr(Me)-arginine vasopressin did not show any differences between the groups. Infusions (i.c.v.) of insulin (8 mU/10 microl) also induced cardiovascular acceleration and augmented the depressor response to i.v. hexamethonium in insulin-infused rats. The i.c.v. pretreatment with the angiotensin II antagonist losartan inhibited the pressor responses to both the i.c.v. and i.v. infusion of insulin. These results suggest that the increase in blood pressure induced by euglycemic hyperinsulinemia is elicited by sympathetic activation and that hyperinsulinemia stimulates the angiotensin system in the brain to increase sympathetic nerve activity.
DOI	10.1097/00005344-199802000-00010
PMID	9475266