モリモト　サトシ   MORIMOTO Satoshi   森本　聡    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Augmented response of endothelin-A and endothelin-B receptor stimulation in coronary arteries of hypertensive hearts.
掲載誌名	正式名：Journal of cardiovascular pharmacology 略　 称：J Cardiovasc Pharmacol ISSNコード：01602446/01602446
掲載区分	国外
巻・号・頁	31 Suppl 1,pp.S94-8
著者・共著者	Miki S, Takeda K, Kiyama M, Hatta T, Morimoto S, Kawa T, Itoh H, Nakata T, Sasaki S, Nakagawa M
発行年月	1998
概要	To determine whether the vasoconstrictor response to endothelin-1 (ET-1) is altered in coronary vessels of hypertensive hearts and the role of ETA and ETB receptors in these responses to ET-1, the vasoconstrictor response to ET-1 in coronary vessels was measured with or without ETA and ETB receptor antagonists. In isolated hearts of spontaneously hypertensive rat (SHR) and normotensive Wistar-Kyoto (WKY) rat, the coronary perfusion pressure was measured on a Langendorff apparatus with constant pressure (75 mm Hg). Coronary perfusion resistance (CPR) (mm Hg/ml/min/g) was calculated. ET-1 elicited dose-dependent increases of CPR in both normotensive and SHR rat hearts. However, the responses were significantly greater in SHR than those of WKY. Pretreatment with the ETA antagonist FR139317 and the ETB antagonist BQ788 inhibited CPR increases with ET-1 infusion. However, vasoconstrictor responses to ET-1 were still greater in SHR than in WKY after FR139317 or BQ788 infusion. These findings suggest that the augmented vasoconstrictor response of coronary artery to ET-1 is mediated by both ETA and ETB receptors. These changes may contribute to the impaired coronary circulation in hypertension.
DOI	10.1097/00005344-199800001-00029
PMID	9595410