MORIMOTO Satoshi
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Visceral fat level is an independent risk factor for cardiovascular mortality in hemodialysis patients.
Journal Formal name:American journal of nephrology
Abbreviation:Am J Nephrol
ISSN code:1421-9670(Electronic)0250-8095(Linking)
Volume, Issue, Page 39(2),pp.122-9
Author and coauthor OKAMOTO Takayuki†, MORIMOTO Satoshi*, IKENOUE Tatsuyoshi, FURUMATSU Yoshiyuki, ICHIHARA Atsuhiro
Authorship 2nd author,Corresponding author
Publication date 2014/05
Summary BACKGROUND:Obesity is an independent risk factor for morbidity and mortality in cardiovascular diseases not only in the general population, but also in hemodialysis (HD) patients. We previously reported that an increased visceral fat area (VFA) determined using computed tomography (CT) scans was associated with atherosclerosis in HD patients. However, whether a high VFA is associated with increased cardiovascular mortality in HD patients remains unknown. Therefore, we investigated the relationship between VFA and prognosis in HD patients.METHODS:VFA was estimated in 126 patients on maintenance HD using CT scans. These patients were followed for 60 months.RESULTS:Kaplan-Meier analysis revealed that the cardiovascular survival rate was significantly lower in the high-VFA group, with a VFA of 71.5 cm(2) or greater, than in the low-VFA group, with a VFA of less than 71.5cm(2). In univariate Cox proportional hazards analyses, age, albumin, low-density lipoprotein cholesterol, cardio-thoracic ratio and VFA above 71.5 cm(2) were significantly correlated with cardiovascular deaths. In multivariate analyses testing these factors as dependent variables, VFA above 71.5 cm(2) was estimated to be an independent predictor of cardiovascular deaths.CONCLUSION:These results suggest that an increased VFA is a stronger risk factor for cardiovascular deaths in HD patients. Measuring VFA may be recommended for predicting the risk of cardiovascular diseases in HD patients.
DOI 10.1159/000358335
Document No. 24503580