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YASUKAWA Kumi
Department School of Medicine(Yachiyo Medical Center), School of Medicine Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Infantile traumatic brain injury with a biphasic clinical course and late reduced diffusion. |
| Journal | Formal name：Journal of the neurological sciences Abbreviation：J Neurol Sci ISSN code：18785883/0022510X |
| Domestic / Foregin | Domestic |
| Volume, Issue, Page | 390,pp.63-66 |
| Author and coauthor | Takase Nanako, Igarashi Noboru, Taneichi Hiromichi, Yasukawa Kumi, Honda Takafumi, Hamada Hiromichi, Takanashi Jun-Ichi |
| Publication date | 2018/07 |
| Summary | Reduced diffusion in the subcortical white matter has been reported in some infants with traumatic brain injury (TBI), including abusive head trauma. However, the pathomechanisms of the lesions and clinical features are uncertain. We herein report two infants with TBI who presented with biphasic clinical courses and late reduced diffusion in the subcortical white matter, and reviewed seven clinically and radiologically similar patients with TBI. Their clinical features (secondary neurological symptoms on days 3 to 6) and radiological findings (normal diffusion on days 1 to 2, followed by reduced diffusion on days 3 to 6) are very similar to those observed in patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). MR spectroscopy in one patient revealed a transient increase of glutamine, which is also observed in AESD, suggesting excitotoxicity as a possible pathomechanism. |
| DOI | 10.1016/j.jns.2018.04.010 |
| PMID | 29801909 |