イチカワ　ナオミ   市川　奈緒美    所属   医学部 医学科（東京女子医科大学病院）    職種   非常勤講師
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Case of Chlamydia-associated arthritis.
掲載誌名	正式名：Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 略　 称：Nihon Rinsho Meneki Gakkai Kaishi ISSNコード：(1349-7413)0911-4300(Linking)
掲載区分	国外
巻・号・頁	32(6),pp.511-4
著者・共著者	Nanke Yuki, Kobashigawa Tsuyoshi, Yago Toru, Ichikawa Naomi, Kamatani Naoyuki, Kotake Shigeru
発行年月	2009/12
概要	We report a case of Chlamydia-associated arthritis in a 40-year-old man. The patient experienced four episodes of Chlamydia trachomatis urtethritis within a few years. During the present episode, polyarthritis developed a few days after Chlamydia trachomatis urethritis was noted. The patient was diagnosed as having Chlamydia-associated arthritis. Loxoprofen sodium and azithromycin were started. Antibiotics induced clinical improvement of urethritis, although arthritis persisted for 3 months. HLA-B27 was negative, but both HLA-B35 and B40 were positive. Thus, we speculate that positivity for both HLA-B35 and HLA-B40 contributed to the persistence of arthritis in this case. During the course, the levels of Th1, Th17 and regulatory T cells in the peripheral blood were increased on flowcytometry. Thus, we speculate that Th17 may play, at least in part, an important role of the pathogenesis in this case.
DOI	10.2177/jsci.32.511
PMID	20046020