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NITTA Masayuki
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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| Article types | Other |
| Language | English |
| Peer review | Non peer reviewed |
| Title | A case of "genetically defined" radiation-induced glioma: 29 years after surgery and radiation for pilocytic astrocytoma. |
| Journal | Formal name：Neuropathology : official journal of the Japanese Society of Neuropathology Abbreviation：Neuropathology ISSN code：14401789/09196544 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 43(5),pp.425-428 |
| Author and coauthor | MASUI Kenta†, NITTA Masayuki, MURAGAKI Yoshihiro, KAWAMATA Takakazu, SATOMI Kaishi, MATSUSHITA Yuko, YOSHIDA Akihiko, ICHIMURA Koichi, TSUDA Masum, TANAKA Shinya, KOMORI Takashi |
| Publication date | 2023/03/22 |
| Summary | Letter to the Editor
Radiation-induced gliomas (RIGs), which occur in a previously irradiated region of the original tumor, represent a rare but well-characterized clinical entity. They are particularly represented as secondary malignancies after irradiation for medulloblastoma (MB) and acute lymphoblastic leukemia (ALL). Clinically well recognized, their genetic characteristics have remained unclear,1 but recent molecular studies revealed their unifying molecular signature for the receptor tyrosine kinase 1 (RTK1) glioblastoma (GBM) subtype.2, 3 We present a case of RIG that emerged 29 years after surgery and radiation for pilocytic astrocytoma (PA); the distinctive molecular features of RIGs enabled its differentiation from malignant transformation of PA. All methods and protocols related to human subjects were approved by each institution's review board ethics committee, and the investigations were carried out in accordance with each institution's review board-approved protocol and Declaration of Helsinki of 2013. |
| DOI | 10.1111/neup.12903 |
| PMID | 36949717 |