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ニツタ マサユキ
NITTA Masayuki
新田 雅之 所属 医学部 医学科（東京女子医科大学病院） 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Tumor volume and calcifications as indicators for preoperative differentiation of grade II/III diffuse gliomas |
| 掲載誌名 | 正式名：Journal of neuro-oncology 略 称：J Neurooncol ISSNコード：15737373/0167594X |
| 掲載区分 | 国外 |
| 巻・号・頁 | 161(3),pp.555-562 |
| 著者・共著者 | FUKUYA Yasukazu†, TAMURA Manabu, NITTA Masayuki, SAITO Taiichi, TSUZUKI Shunsuke, KORIYAMA Shunichi, KUWANO Atsushi, KAWAMATA Takakazu, MURAGAKI Yoshihiro |
| 発行年月 | 2023/02/07 |
| 概要 | PURPOSE:To retrospectively evaluate preoperative clinical factors for their ability to preoperatively differentiate malignancy grades in patients with incipient supratentorial grade II/III diffuse gliomas.METHODS:This retrospective study included 206 adult patients with incipient supratentorial grade II/III diffuse gliomas according to the 2016 World Health Organization classification of tumors of the central nervous system. The cohort included 136 men and 70 women, with a median age of 41 years. Preoperative factors included age, sex, presence of calcifications on computed tomography scans, and preoperative tumor volume measured using preoperative magnetic resonance imaging.RESULTS:In patients with oligodendrogliomas (IDH-mutant and 1p/19q-codeleted), calcifications were significantly more frequent (p = 0.0034) and tumor volume was significantly larger (p < 0.001) in patients with grade III tumors than in those with grade II tumors. Moreover, in patients with IDH-mutant astrocytomas, preoperative tumor volume was significantly larger (p = 0.0042) in patients with grade III tumors than in those with grade II tumors. In contrast, none of the evaluated preoperative clinical factors were significantly different between the patients with grade II and III IDH-wildtype astrocytomas.CONCLUSION:In adult patients with suspicison incipient supratentorial grade II/III diffuse gliomas, presence of calcifications and larger preoperative tumor volume might be used as preoperative indices to differentiate between malignancy grades II and III in oligodendrogliomas (IDH-mutant and 1p/19q-codeleted) and larger preoperative tumor volume might have similar utility in IDH-mutant astrocytomas. |
| DOI | 10.1007/s11060-023-04244-3 |
| PMID | 36749444 |