NITTA Masayuki
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Relationship between characteristics of glioma treatment and surgical site infections.
Journal Formal name：Acta neurochirurgica
Abbreviation：Acta Neurochir (Wien)
ISSN code：09420940/00016268
Domestic / ForeginForegin
Volume, Issue, Page 165(3),pp.659-666
Author and coauthor KUWANO Atsushi†, SAITO Taiichi, NITTA Masayuki, TSUZUKI Shunsuke, KORIYAMA Shunichi, TAMURA Manabu, IKUTA Soko, MASAMUNE Ken, MURAGAKI Yoshihiro, KAWAMATA Takakazu
Publication date 2022/12/31
Summary PURPOSE:Surgical site infections (SSIs) after neurosurgery are common in daily practice. Although numerous reports have described SSIs in neurosurgery, reports specific to gliomas are limited. This study aimed to investigate the relationship between SSIs and glioma treatment characteristics, such as reoperations, radiation therapy, and chemotherapy.METHODS:We examined 1012 consecutive patients who underwent craniotomy for glioma between November 2013 and March 2022. SSIs were defined as infections requiring reoperation during the observation period, regardless of their location. We retrospectively analyzed SSIs and patient factors.RESULTS:During the observation period, SSIs occurred in 3.1% (31/1012). In the univariate analysis, three or more surgeries (P = 0.007) and radiation therapy (P = 0.03) were associated with SSIs, whereas intraoperative magnetic resonance imaging (MRI) was not significantly associated (P = 0.35). Three or more surgeries and radiation therapy were significantly correlated with each other (P < .0001); therefore, they were analyzed separately in the multivariate analysis. Three or more surgeries were an independent factor triggering SSIs (P = 0.02); in contrast, radiation therapy was not an independent factor for SSIs (P = 0.07). Several SSIs localized in the skin occurred more than 1 year after surgery.CONCLUSIONS:Undergoing three or more surgeries for glioma is an independent risk factor for SSIs. Glioma SSIs can occur long after surgery. These results are considered characteristic of gliomas. We recommend careful long-term observation of patients at a high risk of SSIs.
DOI 10.1007/s00701-022-05474-6
PMID 36585974