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NITTA Masayuki
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Effect of Epirubicin Against Glioma Initiating Cells |
| Journal | Formal name：Tokyo Women's Medical University Journal ISSN code：24326186 |
| Domestic / Foregin | Domestic |
| Publisher | 東京女子医科大学学会 |
| Volume, Issue, Page | 4,pp.69-76 |
| Author and coauthor | NAKAJIMA Atsushi† , SAMPETREAN Oltea , KOIKE Naoyoshi, NITTA Masayuki, SAYA Saya, KAWAMATA Takakazu, MURAGAKI Yoshihiro |
| Publication date | 2020/11/21 |
| Summary | Background: Glioblastoma is a highly aggressive primary malignant brain tumor. New treatments, especially ones that can eradicate subpopulations with stem-cell-like properties, are currently being explored. In vitro, epirubicin has demonstrated toxicity towards such populations. However, epirubicin fails to readily cross the blood-brain barrier. Furthermore, its efficacy against stem-like tumor cells growing within the neural tissue has not been fully addressed. Polymeric micelles are an advanced system developed to enhance drug delivery into tumors.
Methods: We have investigated the effect of epirubicin micelles against murine glioma initiating cells (GICs) in vitro and ex vivo. Results: In vitro, epirubicin micelles inhibited the sphere growth of GICs in a dose-dependent manner. Furthermore, they also inhibited the growth of GIC-based tumors in ex vivo cultured brain slices from the tumor-bearing mice. This effect was inversely proportional to the tumor size at the beginning of the treatment. Conclusions: Our results suggest that epirubicin micelles are effective against murine glioma cells with stem cell properties and their use should be initiated at an early stage. |
| DOI | 10.24488/twmuj.2020002 |