NITTA Masayuki    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Assistant Professor
Article types	Review article
Language	English
Peer review	Peer reviewed
Title	Updated therapeutic strategy for adult low-grade glioma stratified by resection and tumor subtype.
Journal	Formal name：Neurologia medico-chirurgica Abbreviation：Neurol Med Chir (Tokyo) ISSN code：04708105/13498029
Domestic / Foregin	Foregin
Volume, Issue, Page	53(7),pp.447-454
Author and coauthor	NITTA Masayuki†, MURAGAKI Yoshihiro, MARUYAMA Takashi, ISEKI Hiroshi, IKUTA Soko, KONISHI Yoshiyuki, SAITO Taichi, TAMURA Manabu, CHERNOV Michael, WATANABE Atsushi, OKAMOTO Saori, MAEBAYASHI Katsuya, MITSUHASHI Norio, OKADA Yoshikazu
Authorship	Lead author,Corresponding author
Publication date	2013/07
Summary	The importance of surgical resection for patients with supratentorial low-grade glioma (LGG) remains controversial. This retrospective study of patients (n = 153) treated between 2000 to 2010 at a single institution assessed whether increasing the extent of resection (EOR) was associated with improved progression-free survival (PFS) and overall survival (OS). Histological subtypes of World Health Organization grade II tumors were as follows: diffuse astrocytoma in 49 patients (32.0%), oligoastrocytoma in 45 patients (29.4%), and oligodendroglioma in 59 patients (38.6%). Median pre- and postoperative tumor volumes and median EOR were 29.0 cm(3) (range 0.7-162 cm(3)) and 1.7 cm(3) (range 0-135.7 cm(3)) and 95%, respectively. Five- and 10-year OS for all LGG patients were 95.1% and 85.4%, respectively. Eight-year OS for diffuse astrocytoma, oligoastrocytoma, and oligodendroglioma were 70.7%, 91.2%, and 98.3%, respectively. Five-year PFS for diffuse astrocytoma, oligoastrocytoma, and oligodendroglioma were 42.6%, 71.3%, and 62.7%, respectively. Patients were divided into two groups by EOR >/=90% and <90%, and OS and PFS were analyzed. Both OS and PFS were significantly longer in patients with >/=90% EOR. Increased EOR resulted in better PFS for diffuse astrocytoma but not for oligodendroglioma. Multivariate analysis identified age and EOR as parameters significantly associated with OS. The only parameter associated with PFS was EOR. Based on these findings, we established updated therapeutic strategies for LGG. If surgery resulted in EOR <90%, patients with astrocytoma will require second-look surgery, whereas patients with oligodendroglioma or oligoastrocytoma, which are sensitive to chemotherapy, will be treated with chemotherapy.
DOI	10.2176/nmc.53.447
PMID	23883555