布村　多佳子
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Pre-conception status, obstetric outcome and use of medications during pregnancy of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) in Japan: Multi-center retrospective descriptive study.
Journal Formal name：Modern rheumatology
Abbreviation：Mod Rheumatol
ISSN code：14397609/14397595
Domestic / ForeginForegin
Volume, Issue, Page 30(5),pp.852-861
Author and coauthor Tsuda Sayaka, Sameshima Azusa, Sekine Michikazu, Kawaguchi Haruna, Fujita Daisuke, Makino Shintaro, Morinobu Akio, Murakawa Yohko, Matsui Kiyoshi, Sugiyama Takao, Watanabe Mamoru, Suzuki Yasuo, Nagahori Masakazu, Murashima Atsuko, Atsumi Tatsuya, Oku Kenji, Mitsuda Nobuaki, Takei Syuji, Miyamae Takako, Takahashi Naoto, Nakajima Ken, Saito Shigeru,
Publication date 2020/09
Summary Objective: To describe the pre-conception status, pregnancy outcomes, and medication prevalence in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Crohn's disease (CD), and ulcerative colitis (UC).Methods: E-mail-based questionnaire survey for the Japan Maternal Fetal Intensive Care Unit Network hospitals inquiring prevalence and clinical features of SLE, RA, CD and UC complicated pregnancies for 2 years.Results: The number of SLE, RA, CD and UC among 69,810 deliveries was 184, 139, 27 and 178, respectively. Less than half of pregnancies were planned. Assisted reproductive technology (ART) pregnancy rates were higher in SLE, RA and UC than in the general population (11.4, 23.0 and 7.4 vs 5.1%, p < .001 each). Preterm delivery, preeclampsia, and fetal growth restriction (FGR) were more frequent in SLE than in the general population (39.4 vs. 5.6% p < .001, 15.0 vs. 6.0% p < .001, 12.9 vs 4.2% p < .001). Prevalence of preterm delivery in RA and UC (27.5 vs. 5.6% p < .001, 11.3 vs. 5.6% p < .05) and FGR in CD (28.6 vs. 4.2% p < .001) was also higher than that in the general population.Conclusion: SLE, RA, CD, and UC complicated pregnancies were at high risks of obstetric adverse outcome. High ART rates necessitate pre-conception counseling in SLE, RA, and UC pregnancies.
DOI 10.1080/14397595.2019.1661592
PMID 31483178