TOKITA Daisuke
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Involvement of tumor necrosis factor-alpha receptor 1 and tumor necrosis factor-related apoptosis-inducing ligand-(TRAIL) receptor-2/DR-5, but not Fas, in graft injury in live-donor liver transplantation. |
Journal | Formal name:Transplant international : official journal of the European Society for Organ Transplantation Abbreviation:Transpl Int ISSN code:09340874/09340874 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 17(10),pp.626-33 |
Author and coauthor | Tashiro Hirotaka, Itamoto Toshiyuki, Ohdan Hideki, Arihiro Kouji, Tateaki Yuko, Nakahara Hideki, Ochi Makoto, Hino Hiroshi, Mizunuma Kazuyuki, Hara Hidetaka, Tokita Daisuke, Onoe Takashi, Ishiyama Kouhei, Mitsuta Hiroshi, Sugino Keizou, Asahara Toshimasa |
Publication date | 2004/11 |
Summary | The pathway leading to cell death in clinical liver transplantation is not known. Eight liver transplant recipients and eight donors were enrolled in this study. Postoperative serum levels of alanine transferase had significantly increased in the recipients compared with those in the donors. Mild centri-lobular necrosis was observed in only liver tissues taken from the recipients. Tumor necrosis factor (TNF)-R1 and death receptor 5 expression levels had increased in liver tissues taken from the recipients. There were no changes in the levels of Fas/Fas ligand expression in liver tissues from either the donors or recipients. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression was down-regulated in donor liver after hepatectomy and liver allograft after implantation. The results suggest that, although ischemic liver injury was not serious, due to the short ischemia time, TNF and TRAIL signals are associated with liver ischemic injury in live-donor liver transplantation but Fas signal is not. |
DOI | 10.1007/s00147-004-0762-z |
PMID | 15502938 |