トキタ ダイスケ   TOKITA Daisuke
  時田 大輔
   所属   医学部 医学科(東京女子医科大学病院)
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Involvement of tumor necrosis factor-alpha receptor 1 and tumor necrosis factor-related apoptosis-inducing ligand-(TRAIL) receptor-2/DR-5, but not Fas, in graft injury in live-donor liver transplantation.
掲載誌名 正式名:Transplant international : official journal of the European Society for Organ Transplantation
略  称:Transpl Int
ISSNコード:09340874/09340874
掲載区分国外
巻・号・頁 17(10),pp.626-33
著者・共著者 Tashiro Hirotaka, Itamoto Toshiyuki, Ohdan Hideki, Arihiro Kouji, Tateaki Yuko, Nakahara Hideki, Ochi Makoto, Hino Hiroshi, Mizunuma Kazuyuki, Hara Hidetaka, Tokita Daisuke, Onoe Takashi, Ishiyama Kouhei, Mitsuta Hiroshi, Sugino Keizou, Asahara Toshimasa
発行年月 2004/11
概要 The pathway leading to cell death in clinical liver transplantation is not known. Eight liver transplant recipients and eight donors were enrolled in this study. Postoperative serum levels of alanine transferase had significantly increased in the recipients compared with those in the donors. Mild centri-lobular necrosis was observed in only liver tissues taken from the recipients. Tumor necrosis factor (TNF)-R1 and death receptor 5 expression levels had increased in liver tissues taken from the recipients. There were no changes in the levels of Fas/Fas ligand expression in liver tissues from either the donors or recipients. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression was down-regulated in donor liver after hepatectomy and liver allograft after implantation. The results suggest that, although ischemic liver injury was not serious, due to the short ischemia time, TNF and TRAIL signals are associated with liver ischemic injury in live-donor liver transplantation but Fas signal is not.
DOI 10.1007/s00147-004-0762-z
PMID 15502938