サトウ キヨウコ   SATO Kyoko
  佐藤 恭子
   所属   医学部 医学科(東医療センター)
   職種   講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 The effect of donepezil treatment on cardiovascular mortality.
掲載誌名 正式名:Clinical pharmacology and therapeutics
略  称:Clin Pharmacol Ther
ISSNコード:(1532-6535)0009-9236(Linking)
掲載区分国外
巻・号・頁 88(3),335-8頁
著者・共著者 Sato K, Urbano R, Yu C, Yamasaki F, Sato T, Jordan J, Robertson D, Diedrich A
発行年月 2010/09
概要 The acetylcholinesterase inhibitor donepezil hydrochloride improves cognitive function in patients with Alzheimer's disease and vascular dementia. Given acetylcholine's important actions on the heart, we undertook a retrospective cohort investigation to assess whether donepezil usage affects cardiovascular mortality. In patients treated with donepezil, hazard ratios for total and cardiovascular mortality were 0.68 (P = 0.045, 95% confidence interval 0.46-0.99) and 0.54 (P = 0.042, 95% confidence interval 0.30-0.98), respectively. The apparent survival benefit in donepezil-treated patients should not be overinterpreted. Prospective clinical trials are warranted.
DOI 10.1038/clpt.2010.98
PMID 20664535