ヤマグチ　ジユンイチ   YAMAGUCHI JUNICHI   山口　淳一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Optimal Blood Pressure in Patients With Coronary Artery Disease and Chronic Kidney Disease: HIJ-CREATE Substudy.
掲載誌名	正式名：The American journal of the medical sciences 略　 称：Am J Med Sci ISSNコード：0002-9629/1538-2990
掲載区分	国外
出版社	Lippincott Williams & Wilkins
巻・号・頁	358(3),pp.219-226
著者・共著者	TANAKA Kazuki†, JUJO Kentaro*, YAMAGUCHI Junichi, OGAWA Hiroshi, HAGIWARA Nobuhisa
発行年月	2019/09
概要	BACKGROUND: Lowering blood pressure (BP) is important in improving the prognosis of hypertensive patients with coronary artery disease (CAD). Patients suffering CAD with chronic kidney disease (CKD) have poorer prognosis than those without CKD. However, there is limited evidence regarding the benefit of BP-lowering therapy on cardiovascular outcomes in patients with CAD and CKD. In this study, we aimed to evaluate the relation between major adverse cardiac events (MACE) and achieved BP in hypertensive patients with CAD and CKD as a high-risk population. METHODS: This study was a post-hoc analysis from the HIJ-CREATE trial, a multicenter, prospective, randomized controlled study comparing the effects of antihypertensive therapy with and without candesartan on MACE in 2049 hypertensive patients with angiographically documented CAD. Of these, 1,002 patients had CKD with a diagnosis of estimated glomerular filtration rate (eGFR) <60 mL/minute/1.73m2. The primary endpoint was the time to first MACE. The participants were divided into quartiles based on the mean systolic or diastolic BP during the follow-up period. RESULTS: Compared between the quartiles, intensive lowering of diastolic BP increased the incidence of MACE in CKD patients; however, intensive lowering of systolic BP did not worsen the incidence of MACE. Therefore, the relationship between achieved diastolic BP and the incidence of MACE showed a "reverse J-shape" curve in the study population. CONCLUSIONS: Intensive lowering of systolic BP in hypertensive patients with CAD and CKD does not correlate with an increased risk of MACE. In contrast, excessive lowering of diastolic BP with antihypertensive treatment results in increased MACE.
DOI	10.1016/j.amjms.2019.06.007
PMID	31324360