SHIMIZU Tatsuya    Department   Research Institutes and Facilities, Research Institutes and Facilities    Position   Professor
Article types	Review article
Language	English
Peer review	Non peer reviewed
Presence of invitation	Invited paper
Title	Cell Sheet-Based Vascularized Myocardial Tissue Fabrication.
Journal	Formal name：European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes Abbreviation：Eur Surg Res ISSN code：(1421-9921)0014-312X(Linking)
Domestic / Foregin	Foregin
Publisher	KARGER
Volume, Issue, Page	59(3-4),pp.276-285
Author and coauthor	KOMAE Hyoe†, ONO Minoru, SHIMIZU Tatsuya*
Authorship	Last author,Corresponding author
Publication date	2018/09
Summary	Our group has reported successful fabrication of thick functional myocardial tissue in vivo and in vitro by using cell sheet engineering technology which requires no scaffolds. Thick myocardial tissue can be fabricated by stacking cardiomyocyte sheets on the vascular bed every 24 h, so that a vascular network can be formed within the myocardial graft. We call this procedure a multi-step transplantation procedure. After human-induced pluripotent stem cells were discovered and human cardiomyocytes became available, a thick, macroscopically pulsate human myocardial tissue was successfully constructed by using a multi-step transplantation procedure. Furthermore, our group succeeded in fabricating functional human myocardial tissue which can generate pressure. Here, we present our way of fabricating human myocardial tissue by means of cell sheet engineering technology. Key Messages: Our group succeeded in fabricating thick, functional human myocardium which can generate pulse pressure. However, there are still a few problems to be solved until clinically functional human cardiac tissue or a whole heart can be fabricated. Research on myocardial regeneration progresses at such a pace that we believe the products of this research will save many lives in the near future.
DOI	10.1159/000492416
PMID	30244251