シミズ タツヤ   SHIMIZU Tatsuya
  清水 達也
   所属   研究施設 研究施設
   職種   教授
論文種別 総説
言語種別 英語
査読の有無 査読なし
招待の有無 招待あり
表題 Cell Sheet-Based Vascularized Myocardial Tissue Fabrication.
掲載誌名 正式名:European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
略  称:Eur Surg Res
ISSNコード:(1421-9921)0014-312X(Linking)
掲載区分国外
出版社 KARGER
巻・号・頁 59(3-4),276-285頁
著者・共著者 KOMAE Hyoe†, ONO Minoru, SHIMIZU Tatsuya*
発行年月 2018/09
概要 Our group has reported successful fabrication of thick functional myocardial tissue in vivo and in vitro by using cell sheet engineering technology which requires no scaffolds. Thick myocardial tissue can be fabricated by stacking cardiomyocyte sheets on the vascular bed every 24 h, so that a vascular network can be formed within the myocardial graft. We call this procedure a multi-step transplantation procedure. After human-induced pluripotent stem cells were discovered and human cardiomyocytes became available, a thick, macroscopically pulsate human myocardial tissue was successfully constructed by using a multi-step transplantation procedure. Furthermore, our group succeeded in fabricating functional human myocardial tissue which can generate pressure. Here, we present our way of fabricating human myocardial tissue by means of cell sheet engineering technology. Key Messages: Our group succeeded in fabricating thick, functional human myocardium which can generate pulse pressure. However, there are still a few problems to be solved until clinically functional human cardiac tissue or a whole heart can be fabricated. Research on myocardial regeneration progresses at such a pace that we believe the products of this research will save many lives in the near future.
DOI 10.1159/000492416
PMID 30244251