シミズ タツヤ   SHIMIZU Tatsuya
  清水 達也
   所属   研究施設 研究施設
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Corneal epithelial stem cell delivery using cell sheet engineering: not lost in transplantation.
掲載誌名 正式名:Journal of drug targeting
略  称:J Drug Target
ISSNコード:(1061-186X)1026-7158(Linking)
掲載区分国外
巻・号・頁 14(7),471-82頁
著者・共著者 YANG Joseph†, YAMATO Masayuki, NISHIDA Kohji, HAYASHIDA Yasutaka, SHIMIZU Tatsuya, KIKUCHI Akihiko, TANO Yasuo, OKANO Teruo*
発行年月 2006/11
概要 Cell-based therapies have now generated significant interest as novel drug delivery systems, with various adult cell types used in treating a wide range of diseases. To overcome the limits that restrict treatments for corneal surface dysfunction, corneal epithelial stem cells expanded ex vivo have been applied as an alternative approach. While previous studies used various carrier substrates, we present a novel method using cell sheet engineering with temperature-responsive culture dishes to create carrier-free corneal epithelial stem cell sheets that can be transplanted without sutures. Results from clinical trials reveal successful transplantation with the recovery of lost visual acuity in all cases. Cell sheet engineering, therefore, presents a novel method for the delivery of corneal epithelial stem cells, and can also be applied for other approaches of cellular therapeutics.
DOI 10.1080/10611860600847997
PMID 17062394