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NARUMIYA Kosuke
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position |
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| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | Prognostic Impact of Pretreatment Serum CYFRA Status in 1047 Patients with Esophageal Squamous Cell Carcinoma Who Underwent Radical Resection: A Japan Esophageal Society Promotion Research. |
| Journal | Formal name：Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia Abbreviation：Ann Thorac Cardiovasc Surg ISSN code：21861005/13411098 |
| Domestic / Foregin | Domestic |
| Volume, Issue, Page | 28(3),pp.163-170 |
| Author and coauthor | ISHIOKA Nobuki, SUZUKI Takashi, YAJIMA Satoshi, MURAKAMI Kentaro, OHKURA Yu, FUKUDA Takashi, YAGI Koichi, OKAMURA Akihiko, HOSHINO Isamu, KUNISAKI Chikara, NANAJIMA Yasuaki, NARUMIYA Kosuke, OGAWA Ryo, SHIMADA Hideaki |
| Publication date | 2022/06 |
| Summary | PURPOSE:The prognostic significance of pretreatment serum C-terminus of cytokeratin 19 (CYFRA21-1, CYFRA) status was evaluated in the patients with surgically treated esophageal squamous cell carcinoma.METHODS:A total of 1047 patients with surgically treated esophageal cancer were enrolled in a multi-institutional study promoted by the Japanese Esophageal Society. This study included an up-front surgery group (n = 412), a neoadjuvant chemotherapy (NAC) group (n = 486), and a neoadjuvant chemoradiation/radiation therapy (NACRT/RT) group (n = 149). The pretreatment CYFRA status was analyzed to assess prognostic significance using multivariate analysis according to treatment modalities.RESULTS:The CYFRA-positive group was significantly associated with deep tumor. Univariate analysis showed that the overall survival of the CYFRA-positive group was significantly worse than that of the CYFRA-negative group, but the difference was not significant in the multivariate analysis. CYFRA was an independent risk factor for poor prognosis just in the NACRT/RT group.CONCLUSIONS:The CYFRA-positive group was associated with deep tumor and poor survival. Pretreatment CYFRA was not an independent risk factor for poor prognosis in the up-front surgery group or NAC group. It was an independent risk factor for poor prognosis just in the NACRT/RT group. |
| DOI | 10.5761/atcs.oa.21-00195 |
| PMID | 34690219 |