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NARUMIYA Kosuke
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Different response rates to chemotherapy between Japanese and German esophageal squamous cell carcinoma: patients may be influenced by ERCC1 or ABCB1. |
| Journal | Formal name：Future oncology (London, England) Abbreviation：Future Oncol ISSN code：17448301/14796694 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 16(27),pp.2075-2087 |
| Author and coauthor | Narumiya Kosuke†*, Bollschweiler Elfriede, Hölscher Arnulf H, Yamamoto Masakazu, Drebber Uta, Alakus Hakan, Metzger Ralf, Warnecke-Eberz Ute |
| Authorship | Lead author,Corresponding author |
| Publication date | 2020/09 |
| Summary | Aim: To find out differences in biomarkers between Japanese and German patients responsible for response after neoadjuvant radio/chemotherapy and survival for esophageal squamous cell carcinoma. Materials & methods: A total of 60 patients from Japan and 127 patients from Germany with esophageal squamous cell carcinoma were analyzed according to three SNPs by real-time PCR. Results: The distribution of the genotypes of ERCC1 rs16115 and ABCB1 C3435T rs1045642 was significantly different between both patients' groups. Japanese patients had significantly less good response to 5-fluorouracil/cisplatin chemotherapy. The influence of the three SNPs on response varied between patients from Japan and Germany. Conclusion: Different expressions of ERCC1 and ABCB1 SNPs of Japanese patients compared with the German patients partially explain the different response. |
| DOI | 10.2217/fon-2020-0489 |
| PMID | 32611208 |