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ナルミヤ コウスケ
NARUMIYA Kosuke
成宮 孝祐 所属 医学部 医学科（東京女子医科大学病院） 職種 非常勤講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Different response rates to chemotherapy between Japanese and German esophageal squamous cell carcinoma: patients may be influenced by ERCC1 or ABCB1. |
| 掲載誌名 | 正式名：Future oncology (London, England) 略 称：Future Oncol ISSNコード：17448301/14796694 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 16(27),pp.2075-2087 |
| 著者・共著者 | Narumiya Kosuke†*, Bollschweiler Elfriede, Hölscher Arnulf H, Yamamoto Masakazu, Drebber Uta, Alakus Hakan, Metzger Ralf, Warnecke-Eberz Ute |
| 担当区分 | 筆頭著者,責任著者 |
| 発行年月 | 2020/09 |
| 概要 | Aim: To find out differences in biomarkers between Japanese and German patients responsible for response after neoadjuvant radio/chemotherapy and survival for esophageal squamous cell carcinoma. Materials & methods: A total of 60 patients from Japan and 127 patients from Germany with esophageal squamous cell carcinoma were analyzed according to three SNPs by real-time PCR. Results: The distribution of the genotypes of ERCC1 rs16115 and ABCB1 C3435T rs1045642 was significantly different between both patients' groups. Japanese patients had significantly less good response to 5-fluorouracil/cisplatin chemotherapy. The influence of the three SNPs on response varied between patients from Japan and Germany. Conclusion: Different expressions of ERCC1 and ABCB1 SNPs of Japanese patients compared with the German patients partially explain the different response. |
| DOI | 10.2217/fon-2020-0489 |
| PMID | 32611208 |