Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Original article
Language English
Peer review Non peer reviewed
Title Intrahepatic Cholangiocarcinoma With Neither Intrahepatic Metastasis Nor Lymph Node Metastasis Is the Optimal Indication for Hepatectomy With Adjuvant Therapy.
Journal Formal name:Cancer diagnosis & prognosis
Abbreviation:Cancer Diagn Progn
ISSN code:27327787/27327787
Domestic / ForeginForegin
Volume, Issue, Page 2(2),pp.160-166
Author and coauthor ARIIZUMI Shunichi†, YAMAMOTO Masakazu, KOTERA Yoshihito, HIGUCHI Ryota, YAMASHITA Shingo, KATO Takaaki, HIRATA YoYoshihiro, KATAGIRI SATOSHI, HONDA Goro, EGAWA Hiroto
Authorship Lead author,Corresponding author
Publication date 2022/03
Summary Background/Aim:The optimal indication of hepatectomy with adjuvant therapy for intrahepatic cholangiocarcinoma (ICC) has not been evaluated in detail.Patients and Methods:We retrospectively studied 224 patients with ICC who underwent hepatectomy between 2000 and 2019. Prognostic factors for overall survival (OS) were evaluated by univariate and multivariate analysis. A total of 127 patients were treated with adjuvant therapy (62 patients with chemotherapy and 65 patients with immunotherapy) after hepatectomy, and 97 patients were treated with hepatectomy alone.Results:Intrahepatic metastasis (IM), lymph node metastasis (LNM) of ICC, adjuvant chemotherapy, and adjuvant immunotherapy were significant prognostic factors for OS on multivariate analysis. In 127 patients with neither IM nor LNM, the 5-year OS rate was significantly higher in 36 patients with adjuvant chemotherapy (81%) and in 34 patients with adjuvant immunotherapy (68%) than in 57 patients with hepatectomy alone (45%).Conclusion:The absence of IM or LNM is the optimal indication for hepatectomy with adjuvant therapy in patients with ICC.
DOI 10.21873/cdp.10090
PMID 35399165