Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Case report
Language English
Peer review Peer reviewed
Title Atypical Sarcoidosis Diagnosed by Massive Splenomegaly.
Journal Formal name:Internal medicine
Abbreviation:Intern Med
ISSN code:13497235/09182918
Domestic / ForeginDomestic
Volume, Issue, Page 59(5),pp.641-648
Author and coauthor SAITO Satomi†, KODAMA Kazuhisa, KOGISO Tomomi*, YAMANASHI Yuki, TANIAI Makiko, ARIIZUMI Shunichi, YAMAMOTO Masakazu, TOKUSHIGE Katsutoshi
Publication date 2020/03
Summary We examined a 22-year-old woman who was admitted to our hospital with abdominal distention. At 19 years of age, the patient presented with hepatosplenomegaly. She was examined several times in another hospital; however, the cause was unidentified. Our evaluation showed severe pancytopenia and a spleen 13×24 cm in size. The serum levels of angiotensin-converting enzyme and lysozyme were elevated. She was diagnosed with liver sarcoidosis based on non-caseating epithelioid granuloma in liver biopsy tissue. To improve the symptoms, splenectomy was performed, and her pancytopenia and symptoms improved. Sarcoidosis should be considered in cases of massive splenomegaly.
DOI 10.2169/internalmedicine.3646-19
PMID 31666466