Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Original article
Language English
Peer review Non peer reviewed
Title Intrahepatic cholangiocarcinoma.
Journal Formal name:Seminars in diagnostic pathology
Abbreviation:Semin Diagn Pathol
ISSN code:(0740-2570)0740-2570(Linking)
Domestic / ForeginForegin
Volume, Issue, Page 34(2),pp.160-166
Author and coauthor NAKANO Masayuki†*, ARIIZUMI Shunichi, YAMAMOTO Msakazu
Authorship 2nd author
Publication date 2017/03
Summary Cholangiocarcinoma, also referred to as cholangiocellular carcinoma (particularly in Japan), develops along the biliary tract. The tumor may be intra- or extrahepatic and have different features with specific treatments based on the site of origin. Guidelines for diagnosis and management of cholangiorcarcinoma, such as those proposed by EASL (European Association for the Study of the Liver)1 and the Mayo Clinic2 classify the tumor into intrahepatic, perihilar, and distal cholangiocarcinoma. There are three main macroscopic patterns of growth of cholangiocarcinoma: mass-forming, periductal-infiltrating and intraductal. A combination of mass-forming and periductal infiltrating tumors have been shown to have a poor prognosis.3 Intrahepatic cholangiocarcinoma (ICC) comprises two microscopic subtypes: bile duct and cholangiolar.4 The bile duct subtype has tall columnar cells that form large glands, whereas cholangiolar tumors are composed of cuboidal and low columnar cells. Patients with cholangiolar tumors, referred to as cholangiolocellular carcinoma, reportedly have a better 5-year survival rate than those with the bile duct type.4.
DOI 10.1053/j.semdp.2016.12.012
PMID 28094162