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カワシマ アキツグ
Akitsugu Kawashima
川島 明次 所属 医学部 医学科（東京女子医科大学病院） 職種 准教授 |
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| 論文種別 | 症例報告 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Infantile Aspergillus fumigatus ventriculitis successfully treated with monitoring of plasma and cerebrospinal fluid voriconazole concentration level. |
| 掲載誌名 | 正式名：Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 略 称：J Infect Chemother ISSNコード：14377780/1341321X |
| 掲載区分 | 国内 |
| 巻・号・頁 | 26(1),pp.132-135 |
| 著者・共著者 | Furudate Aiko, Hirose Shoko, Abe Kota, Kawashima Akitsugu, Hashimoto Kazutoshi, Yamazaki Shingo, Kamei Katsuhiko, Ishiwada Naruhiko, Hamada Hiromichi, Sato Masahiko |
| 発行年月 | 2020/01 |
| 概要 | Aspergillosis is a rare fungal infection in newborns, and its morbidity and mortality are high. Voriconazole (VRCZ) is the first-line antifungal agent for invasive Aspergillus infection, but little data is available about its pharmacokinetics in infants. We report a case of a premature infant who developed ventriculitis due to Aspergillus fumigatus and received combination antifungal therapy including VRCZ. β-D glucan and Aspergillus antigen index were elevated in the cerebrospinal fluid (CSF). We titrated the dose of VRCZ by monitoring plasma and CSF concentrations. The CSF to plasma concentration ratio of VRCZ ranged from 0.47 to 1.36 (median 0.71). While VRCZ adequately penetrates the blood-brain barrier, its concentration is highly variable in infants. |
| DOI | 10.1016/j.jiac.2019.06.011 |
| PMID | 31350185 |