|
Akitsugu Kawashima
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
|
| Article types | Case report |
| Language | English |
| Peer review | Peer reviewed |
| Title | Network-based gene expression analysis of vascular wall of juvenile Moyamoya disease. |
| Journal | Formal name：Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery Abbreviation：Childs Nerv Syst ISSN code：14330350/02567040 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 31(3),pp.399-404 |
| Author and coauthor | Okami Nobuya, Aihara Yasuo, Akagawa Hiroyuki, Yamaguchi Koji, Kawashima Akitsugu, Yamamoto Toshiyuki, Okada Yoshikazu |
| Publication date | 2015/03 |
| Summary | SUBJECTS:Little is known about the pathology and pathogenesis of the Moyamoya disease (MMD). To better understand the molecular processes involved in MMD gene expression analysis of Moyamoya artery tissue to a control artery, this study was conducted.METHODS:Tissue samples of two MMD and two non-MMD were profiled using oligonucleotide microarrays. Gene ontology classification of the differentially expressed genes was analyzed, and regulatory functional networks and pathways were identified with a network-based computational pathway analysis tool. Analysis of MMD and control tissue revealed 104 differentially expressed genes.RESULTS:The two major significantly associated gene ontology terms was cellular development and cellular movement. Further network-based analysis showed significant interaction between RNF213 downstream gene networks and the top 3 score gene networks of MMD. Three major nodes of this network were evident in the merged network and were showing interactions with downstream network of RNF213.CONCLUSIONS:Our results demonstrate that cellular development and cellular movement in MMD are the key role of mechanisms. |
| DOI | 10.1007/s00381-014-2605-2 |
| PMID | 25503250 |