カワシマ　アキツグ   Akitsugu Kawashima   川島　明次    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Network-based gene expression analysis of vascular wall of juvenile Moyamoya disease.
掲載誌名	正式名：Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 略　 称：Childs Nerv Syst ISSNコード：14330350/02567040
掲載区分	国外
巻・号・頁	31(3),pp.399-404
著者・共著者	Okami Nobuya, Aihara Yasuo, Akagawa Hiroyuki, Yamaguchi Koji, Kawashima Akitsugu, Yamamoto Toshiyuki, Okada Yoshikazu
発行年月	2015/03
概要	SUBJECTS:Little is known about the pathology and pathogenesis of the Moyamoya disease (MMD). To better understand the molecular processes involved in MMD gene expression analysis of Moyamoya artery tissue to a control artery, this study was conducted.METHODS:Tissue samples of two MMD and two non-MMD were profiled using oligonucleotide microarrays. Gene ontology classification of the differentially expressed genes was analyzed, and regulatory functional networks and pathways were identified with a network-based computational pathway analysis tool. Analysis of MMD and control tissue revealed 104 differentially expressed genes.RESULTS:The two major significantly associated gene ontology terms was cellular development and cellular movement. Further network-based analysis showed significant interaction between RNF213 downstream gene networks and the top 3 score gene networks of MMD. Three major nodes of this network were evident in the merged network and were showing interactions with downstream network of RNF213.CONCLUSIONS:Our results demonstrate that cellular development and cellular movement in MMD are the key role of mechanisms.
DOI	10.1007/s00381-014-2605-2
PMID	25503250