KURODA Hajime
   Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine
   Position   Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Prognostic impact of a tumor-infiltrating lymphocyte subtype in triple negative cancer of the breast.
Journal Formal name：Breast cancer (Tokyo, Japan)
Abbreviation：Breast Cancer
ISSN code：18804233/13406868
Domestic / ForeginDomestic
Volume, Issue, Page 27(5),pp.880-892
Author and coauthor Jamiyan Tsengelmaa†, Kuroda Hajime*, Yamaguchi Rin, Nakazato Yoshimasa, Noda Shuhei, Onozaki Masato, Abe Akihito, Hayashi Mitsuhiro
Authorship 2nd author,Corresponding author
Publication date 2020/03
Summary BACKGROUND:Tumor-infiltrating lymphocytes (TILs) have recently been reported as an important factor in the tumor microenvironment and influence the growth and progression of cancer. However, the relationship between immune cell subpopulations, such as CD4+, CD8+, and FOXP3+, in breast cancer, especially in triple negative carcinoma (TNC), remains unclear.METHODS:The subjects were 107 patients with TNC that were surgically resected at Dokkyo Medical University Hospital between 2006 and 2018. The expression of CD4+, CD8+, and FOXP3+ was evaluated in TILs and expressed as the numbers of positive cells.RESULTS:Univariate analysis revealed that the TILs were not prognostically significant. In multivariate analyses, increased infiltration of intratumoral (i) CD4+ TILs was found to have a good prognosis in relapse-free survival (RFS). In contrast, a high stromal CD8+ TILs level was found to be a favorable prognostic factor in RFS (p = 0.038) and overall survival (OS) (p = 0.046). A low sFOXP3 + TILs level was significantly associated with favorable RFS (p < 0.001) and OS (p = 0.029).CONCLUSIONS:The present study demonstrated no difference in TILs and survival in TNC. However, there was a significant correlation in prognosis with levels of iCD4+, sCD8+, and sFOXP3 + TILs in TNC. The difference in TNC clinical outcome may be due to the subtype of the infiltrating TILs.
DOI 10.1007/s12282-020-01084-1
PMID 32222891