KURODA Hajime
   Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine
   Position   Professor
Article types Case report
Language English
Peer review Peer reviewed
Title Liposarcoma of the uterine corpus: A case report and literature review.
Journal Formal name：Gynecologic oncology reports
Abbreviation：Gynecol Oncol Rep
ISSN code：23525789/23525789
Domestic / ForeginForegin
Volume, Issue, Page 26,pp.78-81
Author and coauthor Kiuchi Kaori, Hasegawa Kiyoshi, Ochiai Shoko, Kosaka Nobuaki, Kuroda Hajime, Kaji Yasushi, Fukasawa Ichio
Publication date 2018/11
Summary Liposarcoma of the uterine corpus is extremely rare. We performed a laparotomy on a 55-year-old woman with the complaints of abdominal distension and genital bleeding who was found to have a uterine tumor, 17 × 16 cm in diameter. The preoperative diagnosis was a lipoma or lipoleiomyoma of the uterine corpus. However, pathological examination revealed proliferation of mature adipocytes and lipoblast-like atypical cells with small, weakly pleomorphic nuclei and foamy or vacuolated cytoplasm present within a fibrous septum. Immunohistochemistry showed that the tumor cells were focally positive for mouse double minute 2 homolog (MDM2). The final pathological diagnosis was a well-differentiated liposarcoma of International Federation of Gynecology and Obstetrics (FIGO) stage IB (pT1bNxM0). On magnetic resonance imaging (MRI), T1 -weighted and fat-saturated images showed high and low intensity in the tumor, respectively, suggesting that this tumor contained a fat component. The septum inside the tumor had a contrast enhancement on T1-weighted, gadolinium-enhanced imaging. The septum was nonuniformly thickened and partially nodular. In hindsight, these findings may have suggested a well-differentiated liposarcoma in the uterine corpus rather than a lipoma or lipoleiomyoma. Clinicians should be aware of the possibility of a liposarcoma of the uterine corpus when a neoplasm contains adipose tissue and a nonuniformly thickened or partially nodular septum on MRI.
DOI 10.1016/j.gore.2018.10.008
PMID 30386812