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KURODA Hajime
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | α-taxilin overexpression correlates with proliferation activity but not with prognosis of colorectal cancer. |
| Journal | Formal name：Oncology letters Abbreviation：Oncol Lett ISSN code：17921074/17921074 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 14(2),pp.1471-1476 |
| Author and coauthor | Kanamori Akira, Imai Yasuo, Ihara Keisuke, Nagata Hitoshi, Nakano Masakazu, Tominaga Keiichi, Shimizu Hiroaki, Makiyama Tomihiko, Kuroda Hajime, Shirataki Hiromichi, Hiraishi Hideyuki |
| Publication date | 2017/08 |
| Summary | α-taxilin is a binding partner of syntaxins, which are the central coordinators of membrane traffic. Expression of α-taxilin has been implicated in the development of human glioblastoma, hepatocellular carcinoma and renal cell carcinoma. In the present study, the clinical significance of α-taxilin expression in colorectal cancer (CRC) was investigated. A total of 20 cases of colorectal intramucosal adenocarcinoma (IMA) with adenoma were analyzed using immunohistochemical analysis. The results demonstrated that α-taxilin expression was significantly associated with Ki-67 indices in adenoma and IMA. The patients expressed equally high levels of α-taxilin in the upper third of the intramucosal glands. These results suggest that α-taxilin expression is significantly associated with the proliferative activity of CRC, but that its overexpression alone is not a biomarker of malignancy. Next, α-taxilin expression was investigated in 57 advanced CRCs and its association with prognosis was determined. Well-differentiated and/or moderately differentiated adenocarcinomas in the left-sided colon with anatomic stage II and/or III were analyzed. α-taxilin expression levels were high on the surface of nearly all tumors, but variable at the deep advancing edge. α-taxilin levels at the advancing edge were not significantly associated with local invasiveness or prognosis. In conclusion, α-taxilin is a cell proliferation marker in colorectal epithelial neoplasms but cannot be a marker of malignancy or prognosis of CRCs. |
| DOI | 10.3892/ol.2017.6309 |
| PMID | 28789367 |