クロダ　ハジメ   KURODA Hajime   黒田　一    所属   医学部 医学科（附属足立医療センター）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Molecular pathogenesis of sporadic colorectal cancers.
掲載誌名	正式名：Chinese journal of cancer 略　 称：Chin J Cancer ISSNコード：1944446X/1944446X
掲載区分	国外
巻・号・頁	35,pp.4
著者・共著者	Yamagishi Hidetsugu, Kuroda Hajime†, Imai Yasuo, Hiraishi Hideyuki
担当区分	筆頭著者
発行年月	2016/01
概要	Colorectal cancer (CRC) results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to adenocarcinoma. Approximately 75% of CRCs are sporadic and occur in people without genetic predisposition or family history of CRC. During the past two decades, sporadic CRCs were classified into three major groups according to frequently altered/mutated genes. These genes have been identified by linkage analyses of cancer-prone families and by individual mutation analyses of candidate genes selected on the basis of functional data. In the first half of this review, we describe the genetic pathways of sporadic CRCs and their clinicopathologic features. Recently, large-scale genome analyses have detected many infrequently mutated genes as well as a small number of frequently mutated genes. These infrequently mutated genes are likely described in a limited number of pathways. Gene-oriented models of CRC progression are being replaced by pathway-oriented models. In the second half of this review, we summarize the present knowledge of this research field and discuss its prospects.
DOI	10.1186/s40880-015-0066-y
PMID	26738600