クロダ　ハジメ   KURODA Hajime   黒田　一    所属   医学部 医学科（附属足立医療センター）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Differential expression of glu-tubulin in relation to mammary gland disease.
掲載誌名	正式名：Virchows Archiv : an international journal of pathology 略　 称：Virchows Arch ISSNコード：14322307/09456317
掲載区分	国外
巻・号・頁	457(4),pp.477-82
著者・共著者	Kuroda Hajime†*, Saito Ken, Kuroda Mina, Suzuki Yutaka
担当区分	筆頭著者,責任著者
発行年月	2010/10
概要	Tubulin is one of the molecular components that regulate cytosketal structure relating to cell differentiation, invasion, and metastasis in cancer. Recently, glu-tubulin, in which the C-terminal tyrosine of α-tubulin is removed by tubulin carboxypeptidase, overexpression has been reported in malignant tumors of the mammary gland immunohistochemically. We identified 147 cases accessioned in the Department of Pathology, International University of Health and Welfare Hospital from 2003 to 2009. Of the 78 malignant tumor cases, staining for glu-tubulin was observed in 56 (71.8%), and only 22 cases showed no significant staining. However, in benign disease, glu-tubulin staining was detected in the cytoplasm of fibroblasts and endothelial cells, but was completely absent from epithelial cells in 64 of 69 cases. When the expression of glu-tubulin was compared between malignant tumor, benign tumor, and other benign disease, a significant differentiation was found among expressions of this protein. These results indicate that glu-tubulin represents a strong selective expression for cancer cells and may be useful to identify and quantify human breast cancer.
DOI	10.1007/s00428-010-0955-z
PMID	20697907