KURODA Hajime
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Professor |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Basal cytokeratin expression in relation to biological factors in breast cancer. |
Journal | Formal name:Human pathology Abbreviation:Hum Pathol ISSN code:15328392/00468177 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 39(12),pp.1744-50 |
Author and coauthor | Kuroda Hajime†*, Ishida Fumitaka, Nakai Maki, Ohnisi Kiyoshi, Itoyama Shinji |
Authorship | Lead author,Corresponding author |
Publication date | 2008/12 |
Summary | The objective of this study was to determine the predictive impact of several established tumor biological markers and clinicopathological findings for basal-like carcinoma. Expression was determined by immunohistochemistry using antibodies to cytokeratins 5/6, 14, and 17, and the cases were divided into basal-like carcinoma and non basal-like carcinoma. These subgroups were compared in terms of biological markers (HER2, estrogen receptor, progesterone receptor, Ki-67, P-53, and P-glycoprotein) and clinicopathological behavior. Of the 49 basal-like carcinoma cases, 25(51.0%) were P-53-positive, whereas 100 (35.9%) of the 278 non basal-like carcinoma cases were P-53-positive. A high ratio of nuclear Ki-67 expression was detected in 39 (79.6%) of 49 basal-like carcinoma cases and was significantly more common than in non basal-like carcinoma cases (81/278, 29.1%). P-glycoprotein expression was identified in 29 (59.2%) of 49 basal-like carcinomas but only 85 (30.6%) of 278 non basal-like carcinomas. We observed high levels of P-53, Ki-67, and P-glycoprotein, with the reduction or loss of estrogen receptor, progesterone receptor, and HER2 being more obvious, in basal-like carcinomas than in non basal-like carcinomas. Our findings provide further evidence that basal-like carcinoma has different mechanisms of histogenesis. |
DOI | 10.1016/j.humpath.2008.06.007 |
PMID | 18755493 |