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OKANO Teruo
Department Research Institutes and Facilities, Research Institutes and Facilities Position |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Adult hepatocytes direct liver organogenesis through non-parenchymal cell recruitment in the kidney. |
| Journal | Formal name：Journal of hepatology Abbreviation：J Hepatol ISSN code：(1600-0641)0168-8278(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 68(4),pp.744-753 |
| Author and coauthor | UTOH Rie†, KOMORI Junji, KUGE Hiroyuki, TATSUMI Kohei, YAMADA Masumi, HIROHASHI Shinji, TSUTSUMI Masahiro, AMANUMA Toshihiro, YOSHIOKA Akira, NAKAJIMA Yoshiyuki, WAKE Kenjiro, OKANO Teruo, LAGASSE Eric, OHASHI Kazuo* |
| Publication date | 2018/04 |
| Summary | The role of adult hepatocytes at ectopic locations has not been clarified. In this study, we demonstrated that engrafted hepatocytes in the kidney proliferated, recruited non-parenchymal cells from host tissues including bone marrow, and finally created an organ-sized, complex liver system that exhibited liver-specific architectures and functions. Our results revealed previously undescribed functions of hepatocytes to direct liver organogenesis through non-parenchymal cell recruitment and organize multiple cell types into a complex 3D liver at ectopic sites. Transcript profiling: Microarray data are deposited in GEO (GEO accession: GSE99141). |
| DOI | 10.1016/j.jhep.2017.12.016 |
| PMID | 29288124 |