オカノ　テルオ   OKANO Teruo   岡野　光夫    所属   研究施設 研究施設    職種   特任顧問
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Adult hepatocytes direct liver organogenesis through non-parenchymal cell recruitment in the kidney.
掲載誌名	正式名：Journal of hepatology 略　 称：J Hepatol ISSNコード：(1600-0641)0168-8278(Linking)
掲載区分	国外
巻・号・頁	68(4),pp.744-753
著者・共著者	UTOH Rie†, KOMORI Junji, KUGE Hiroyuki, TATSUMI Kohei, YAMADA Masumi, HIROHASHI Shinji, TSUTSUMI Masahiro, AMANUMA Toshihiro, YOSHIOKA Akira, NAKAJIMA Yoshiyuki, WAKE Kenjiro, OKANO Teruo, LAGASSE Eric, OHASHI Kazuo*
発行年月	2018/04
概要	The role of adult hepatocytes at ectopic locations has not been clarified. In this study, we demonstrated that engrafted hepatocytes in the kidney proliferated, recruited non-parenchymal cells from host tissues including bone marrow, and finally created an organ-sized, complex liver system that exhibited liver-specific architectures and functions. Our results revealed previously undescribed functions of hepatocytes to direct liver organogenesis through non-parenchymal cell recruitment and organize multiple cell types into a complex 3D liver at ectopic sites. Transcript profiling: Microarray data are deposited in GEO (GEO accession: GSE99141).
DOI	10.1016/j.jhep.2017.12.016
PMID	29288124