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論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Bio-implant as a novel restoration for tooth loss.
掲載誌名	正式名：Scientific reports 略　 称：Sci Rep ISSNコード：(2045-2322)2045-2322(Linking)
掲載区分	国外
巻・号・頁	7(1),pp.7414
著者・共著者	LEE Dong-Joon†, LEE Jong-Min, KIM Eun-Jung, TAKATA Takashi, ABIKO Yoshihiro, OKANO Teruo, GREEN David W, SHIMONO Masaki, JUNG Han-Sung*
発行年月	2017/08
概要	A dental implant is used to replace a missing tooth. Fixing the implant in its natural position requires the engineering of a substantial amount of conformal bone growth inside the implant socket, osseointegration. However, this conventional implant attachment does not include the periodontal ligament (PDL), which has a fundamental role in cushioning high mechanical loads. As a result, tooth implants have a shorter lifetime than the natural tooth and have a high chance of infections. We have engineered a "bio-implant" that provides a living PDL connection for titanium implants. The bio-implant consists of a hydroxyapatite coated titanium screw, ensheathed in cell sheets made from immortalized human periodontal cells. Bio-implants were transplanted into the upper first molar region of a tooth-extraction mouse model. Within 8 weeks the bio-implant generated fibrous connective tissue, a localised blood vessel network and new bone growth fused into the alveolar bone socket. The study presents a bio-implant engineered with human cells, specialised for the root connection, and resulted in the partial reconstruction of a naturalised tooth attachment complex (periodontium), consisting of all the principal tissue types, cementum, PDL and alveolar bone.
DOI	10.1038/s41598-017-07819-z
PMID	28784994