ISEKI Hiroshi    Department   Research Institutes and Facilities, Research Institutes and Facilities    Position
Article types	Other
Language	English
Peer review	Peer reviewed
Title	A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection
Journal	Formal name：Med Image Comput Comput Assist Interv
Domestic / Foregin	Foregin
Publisher	© Springer-Verlag Berlin Heidelberg 2006
Volume, Issue, Page	9(Pt 1),pp.543-550
Author and coauthor	NOGUCHI Masafumi †, AOKI Eisuke , YOSHIDA Daiki , KOBAYASHI Etsuko , OMORI Shigeru , MURAGAKI Yoshihiro, ISEKI Hiroshi, NAKAMURA Katsushige , SAKUMA Ichiro
Publication date	2006/02
Summary	We developed a combined system of tumor detection by 5-ALA-induced PpIX fluorescence and precise ablation by micro laser for the first time, with an automatic focusing and robotic scanning mechanism for the brain surface. 5-ALA accumulates on tumors to be metabolized to become PpIX that is a fluorescent. Intra-operative detection of 5-ALA induced PpIX fluorescence provides useful information for tumor detection. The wavelength of the micro laser is 2.8 microm close to the absorption band of water. This laser is effective only on the surface of brain tissue, enabling precise ablation at the boundary between tumor and normal tissue identified by intra-operative 5-ALA induced fluorescence. Combination tests of the fluorescence measurement and the laser ablation were performed, and it was possible to extract the area with fluorescence appropriately from the measurement data, and the micro laser with automatically scanning selectively ablated the extracted area.
Document No.	17354933