石井　泰雄    Department   Center for Medical and Nursing Education, Center for Medical and Nursing Education    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Region-specific expression of chicken Sox2 in the developing gut and lung epithelium: regulation by epithelial-mesenchymal interactions.
Journal	Formal name：Developmental dynamics : an official publication of the American Association of Anatomists Abbreviation：Dev Dyn ISSN code：(1058-8388)1058-8388(Linking)
Domestic / Foregin	Foregin
Volume, Issue, Page	213(4),pp.464-75
Author and coauthor	Ishii Y, Rex M, Scotting P J, Yasugi S
Authorship	Lead author
Publication date	1998/12
Summary	In situ analysis of the chicken cSox2 gene, a member of the transcription factor family containing an Sry-like high-mobility group (HMG) box, demonstrated localized expression in the embryonic endoderm. Transcripts of cSox2 appeared before commencement of morphogenesis and cytodifferentiation in the rostral gut epithelium from the pharynx to the stomach. The caudal limit of cSox2 expression coincided with that of the region competent for proventricular differentiation and to the rostral limit of the domain of CdxA, a homologue of Drosophila caudal. During morphogenesis, the level of transcripts of cSox2 decreased in epithelia invaginating into surrounding mesenchyme to form glandular or tubular structures, such as the primordia of the thyroid and lung, glandular epithelium of the proventriculus, and secondary bronchus of the lung. Tissue recombination experiments demonstrated that cSox2 expression is regulated by the underlying mesenchyme as well as morphogenesis and cytodifferentiation. The results suggest that cSox2 plays pivotal roles in generating morphologically and physiologically distinct types of epithelial cells in the gut.
DOI	10.1002/(SICI)1097-0177(199812)213:4<464::AID-AJA11>3.0.CO;2-Z
PMID	9853967