|
石井 泰雄
Department Center for Medical and Nursing Education, Center for Medical and Nursing Education Position Assistant Professor |
|
| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Pax6 controls the expression of Lewis x epitope in the embryonic forebrain by regulating alpha 1,3-fucosyltransferase IX expression. |
| Journal | Formal name：The Journal of biological chemistry Abbreviation：J Biol Chem ISSN code：(0021-9258)0021-9258(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 277(3),pp.2033-9 |
| Author and coauthor | Shimoda Yasushi, Tajima Youichi, Osanai Taka, Katsume Asao, Kohara Michinori, Kudo Takashi, Narimatsu Hisashi, Takashima Noriko, Ishii Yasuo, Nakamura Shun, Osumi Noriko, Sanai Yutaka |
| Publication date | 2002/01 |
| Summary | Pax6 is a transcription factor involved in brain patterning and neurogenesis. Expression of Pax6 is specifically observed in the developing cerebral cortex, where Lewis x epitope that is thought to play important roles in cell interactions is colocalized. Here we examined whether Pax6 regulates localization of Lewis x using Pax6 mutant rat embryos. The Lewis x epitope disappeared in the Pax6 mutant cortex, and activity of alpha1,3-fucosyltransferase, which catalyzed the last step of Lewis x biosynthesis, drastically decreased in the mutant cortex as compared with the wild type. Furthermore, expression of a fucosyltransferase gene, FucT-IX, specifically decreased in the mutant, while no change was seen for expression of another fucosyltransferase gene, FucT-IV. These results strongly suggest that Pax6 controls Lewis x expression in the embryonic brain by regulating FucT-IX gene expression. |
| DOI | 10.1074/jbc.M108495200 |
| PMID | 11675393 |