イシイ ヤスオ
  石井 泰雄
   所属   統合教育学修センター 統合教育学修センター
   職種   講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Pax6 controls the expression of Lewis x epitope in the embryonic forebrain by regulating alpha 1,3-fucosyltransferase IX expression.
掲載誌名 正式名:The Journal of biological chemistry
略  称:J Biol Chem
ISSNコード:(0021-9258)0021-9258(Linking)
掲載区分国外
巻・号・頁 277(3),pp.2033-9
著者・共著者 Shimoda Yasushi, Tajima Youichi, Osanai Taka, Katsume Asao, Kohara Michinori, Kudo Takashi, Narimatsu Hisashi, Takashima Noriko, Ishii Yasuo, Nakamura Shun, Osumi Noriko, Sanai Yutaka
発行年月 2002/01
概要 Pax6 is a transcription factor involved in brain patterning and neurogenesis. Expression of Pax6 is specifically observed in the developing cerebral cortex, where Lewis x epitope that is thought to play important roles in cell interactions is colocalized. Here we examined whether Pax6 regulates localization of Lewis x using Pax6 mutant rat embryos. The Lewis x epitope disappeared in the Pax6 mutant cortex, and activity of alpha1,3-fucosyltransferase, which catalyzed the last step of Lewis x biosynthesis, drastically decreased in the mutant cortex as compared with the wild type. Furthermore, expression of a fucosyltransferase gene, FucT-IX, specifically decreased in the mutant, while no change was seen for expression of another fucosyltransferase gene, FucT-IV. These results strongly suggest that Pax6 controls Lewis x expression in the embryonic brain by regulating FucT-IX gene expression.
DOI 10.1074/jbc.M108495200
PMID 11675393