石井 泰雄
   Department   Center for Medical and Nursing Education, Center for Medical and Nursing Education
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Sox3 expression defines a common primordium for the epibranchial placodes in chick.
Journal Formal name:Developmental biology
Abbreviation:Dev Biol
ISSN code:(0012-1606)0012-1606(Linking)
Domestic / ForeginForegin
Volume, Issue, Page 236(2),pp.344-53
Author and coauthor Ishii Y, Abu-Elmagd M, Scotting P J
Authorship Lead author
Publication date 2001/08
Summary The epibranchial placodes are ectodermal thickenings that generate sensory neurons of the distal ganglia of the branchial nerves. Although significant advances in our understanding of neurogenesis from the placodes have recently been made, the events prior to the onset of neurogenesis remain unclear. We found that chick Sox3 (cSox3) shows a highly dynamic pattern of expression before becoming confined to the final placodes: one pre-otic (geniculate) and three post-otic (one petrosal and two nodose) placodes. A fate-mapping study using lipophilic dyes revealed that all post-otic placodes arise within a single broad cSox3-positive domain, where cSox3 expression and epithelial thickness will be retained only in much smaller final neurogenic placodes. The data presented here suggest that post-otic placodes are remnants of a common primordium defined as a discrete domain of cSox3 expression.
DOI 10.1006/dbio.2001.0318
PMID 11476576